Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer
نویسندگان
چکیده
منابع مشابه
Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer
BACKGROUND MLL3 is a histone 3-lysine 4 methyltransferase with tumor-suppressor properties that belongs to a family of chromatin regulator genes potentially altered in neoplasia. Mutations in MLL3 were found in a whole genome analysis of colorectal cancer but have not been confirmed by a separate study. METHODS AND RESULTS We analyzed mutations of coding region and promoter methylation in MLL...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0023320